The Rabbit Anti-Superoxide dismutase 1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to SOD1, and Superoxide Dismutase 1. This antibody recognizes Human antigen. The Rabbit Anti-Superoxide dismutase 1 Antibody has been validated for the following applications: Blotting, and Western Blot.
Description
Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme that catalyzes the dismutation of the superoxide radical O2-to oxygen and hydrogen peroxide which are then metabolized to H2O and O2 by catalase and glutathione peroxidase. SODs play an important role in antioxidant defense mechanisms. Three different SOD isoenzymes are found in mammalian cells: SOD1, SOD2, and SOD3. SOD1 contains Cu and Zn ions and exists as a homodimer in cell cytoplasm. The two subunits of ~16kDa each are linked by two cysteines that form an intrasubunit disulfide bridge. Misfolding of SOD1 has been implicated in Amyotrophic Lateral Sclerosis (ALS)